Estrogen receptor 1 mutations in 260 cervical cancer samples from Chinese patients
نویسندگان
چکیده
منابع مشابه
Estrogen receptor mutations and splice variants determined in liquid biopsies from metastatic breast cancer patients
Mutations and splice variants in the estrogen receptor (ER) gene, ESR1, may yield endocrine resistance in metastatic breast cancer (MBC) patients. These putative endocrine resistance markers are likely to emerge during treatment, and therefore, its detection in liquid biopsies, such as circulating tumor cells (CTCs) and cell-free DNA (cfDNA), is of great interest. This research aimed to determi...
متن کاملPrognostic Impact of Progesterone Receptor Status in Chinese Estrogen Receptor Positive Invasive Breast Cancer Patients
PURPOSE Estrogen receptor (ER) and progesterone receptor (PR) have been used as indicators of endocrine system status since the mid-1970s in the clinical management of breast cancer. The predictive role of ER in endocrine therapy is undisputed, but the prognostic value of PR is still debated. The aim of this study was to investigate the clinical characteristics and prognosis of ER positive brea...
متن کاملRelation between Estrogen and Progesterone Receptor Status with p53, Ki67 and Her-2 Markers in Patients with Breast Cancer
Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...
متن کاملpromoter hypermethylation of estrogen receptor alpha gene is correlated to estrogen receptor negativity in iranian patients with sporadic breast cancer
objective: breast cancer is the most common cancer in iranian women. breast tumors are classified based on the estrogen receptor alpha (erα) expression status into er negative and er positive tumors. er negative tumors tend to have worse prognosis and less likely to respond to endocrine therapy. aberrant methylation of gene promoter is one of the mechanisms for gene silencing in breast tumors. ...
متن کاملThe Exogenous Estrogen Antiproliferaive Effects On Cervical Cancer Cell Line: An In Vitro Study
Estradiol valerate (Exogenous estrogen) is a synthetic ester and is also a female estrogen hormone. There arestudies showing that estradiol may have anticancer effects. This study was performed to reveal the effects ofexogenous estrogens on the viability of cervical cancer cells in cell culture. We used Hela cells as our cell linein this study. Hela cells were exposed to 0.0001, 0.001, 0.01, 0....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncology Letters
سال: 2019
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2019.10612